I wanted one of my first blog posts to be about something that has been dominating headlines and causing significant concern for a number of years now—fentanyl. Now, first and foremost, I’m not here to lecture you, and tell you not to do drugs or share more horror stories of fentanyl because I think it’s safe to say that at this point nearly everyone knows just how deadly and dangerous Fentanyl is. Instead, I’m here to provide vital insights, underscore critical global trends and facts, and offer a few reflections on this potent substance that has been making seismic waves in the world of drugs while tragically claiming too many lives in its wake.

10 Key Facts

Before I go into the details, let’s take a moment to dive into some essential facts about fentanyl that can help paint a clearer picture:

  1. Potency Beyond Comparison: Fentanyl is astonishingly potent, it is estimated to be up to 100 times more potent than morphine and around 50 times more potent than heroin, making even a minuscule amount potentially lethal.
  2. High Deathrate: The latest CDC report for 2023 shows that over 110,000 people lost their life to an overdose, the highest number ever recorded. Fentanyl was the top contributor of these unnecessary deaths.
  3. Medical Usage: Fentanyl is used medically for pain management, particularly for severe and chronic pain situations, such as cancer-related pain or post-surgery recovery. It’s available in various forms, including patches, lozenges, injections, and more.
  4. Synthetic Origin: Fentanyl is a synthetic opioid, meaning it’s created in a laboratory rather than derived from natural sources like opium poppies.
  5. Illicit Production and Global Impact: The illicit production and distribution of fentanyl is a global concern. It’s often manufactured in clandestine labs, with criminal organizations contributing to its worldwide distribution. The illicit distribution has had a significant impact worldwide, leading to increased overdose deaths in various countries. Its potency poses a particular challenge for harm reduction efforts around the globe.
  6. Illicit Fentanyl Analogues: In addition to fentanyl itself, various fentanyl analogues have emerged, each with different chemical structures and potencies. These analogues are often designed to circumvent legal restrictions but carry similar risks.
  7. Dark Web Trade: Illicit fentanyl trade has expanded to the dark web, allowing sellers to access a global market discreetly. This has made it difficult for law enforcement to track and curb its distribution effectively.
  8. Intercontinental Routes: Illicit fentanyl is transported through various routes, including land, air, and sea. It’s often hidden in creative ways to avoid detection by law enforcement.
  9. Challenges in Regulation: Fentanyl’s international distribution poses regulatory challenges due to its varying legality across different countries. Coordination among nations is crucial to combating its spread and impact.
  10. Naloxone for Overdose Reversal: Naloxone (Narcan) is a lifesaving medication used to reverse opioid overdoses, including those involving fentanyl. Widespread access to naloxone, as well as an understanding of proper dosage, is vital to prevent fatal overdoses.

Origins and an International Crisis

Fentanyl’s story begins in the realm of legitimate medical use and was first developed in 1959 by Belgian chemist Paul Janssen. It was initially developed to manage severe pain, often in medical settings like hospitals. However, its potential for misuse and abuse didn’t go unnoticed. Illicit fentanyl started appearing on the streets, often mixed with other drugs like heroin or cocaine, adding an element of Russian roulette to the already risky game of substance use.

What’s particularly alarming is that fentanyl’s influence knows no borders. It’s not just a regional issue; it’s a global one. The United States and Canada are simultaneously grappling with their own fentanyl epidemics. It appears that these two geographical neighbors are sharing more than just a border. Fentanyl’s reach is extensive and is primarily being fueled by Illicit labs in Mexico that are using chemicals from China and are being trafficked throughout the Northern Hemisphere. It goes to show how the international origins impacts lives halfway across the globe. The international distribution of fentanyl adds a layer of complexity to tackling its presence and impact.

Understanding The Allure of Fentanyl: A Potent Force

Fentanyl isn’t just your run-of-the-mill opioid—it’s a synthetic opioid, which means it’s man-made, designed in the lab to mimic the effects of natural opiates like morphine. But here’s where it gets serious: fentanyl is exceptionally powerful. In fact, it’s estimated to be anywhere from 50 to 100 times more potent than morphine. That potency comes with an alarming risk factor—one miscalculation, and the consequences can be deadly. This is why we are seeing more overdoses than ever before because it’s very easy overdose. In addition, many people are unaware that they are consuming Fentanyl because dealers are using fentanyl to put into other drugs such as heroin, cocaine, Xanax, and even marijuana to make them more addicting. The consequences are dire and have caused an unthinkable number of deaths from individuals who did not know they had ingested fentanyl.

The Seductive Allure and the Terrifying Reality

I get it; the allure of fentanyl might be hard to grasp. Why would anyone willingly mess with something so potent and potentially deadly? Well, therein lies the complex relationship between individuals and substances, especially as it relates to dopamine, the oh so good and oh so problematic neurotransmitter that has a lot to do with addiction because of how it affects both pain and pleasure in our brain; fentanyl creates an enormous spike of dopamine. While this surge of dopamine might initially feel incredible, it can lead to a problematic cycle. Your brain remembers the extreme pleasure caused by fentanyl and starts craving it more and more. Over time, the brain’s natural reward circuitry can become rewired, making you associate pleasure primarily with fentanyl.  Some people may be more naturally drawn to fentanyl’s intense effects, seeking that quick and overwhelming high. But let’s be crystal clear: fentanyl’s potency is its curse just as much as its allure. It’s a dangerous gamble—one that can lead to overdose, hospitalization, or death.

Final Thoughts

Fentanyl isn’t just a news headline—it’s a potent force that has made its presence known in the lives of countless individuals and families. In 2022 the United States had the deadliest year for overdoses ever recorded, over 110,000 people lost their lives- and fentanyl was the driving force that was responsible for these deaths. I have personally lost people, as I am sure many of you reading this have. I have been fighting back against fentanyl for the past few years by designing treatment programs, working with task forces, non-profits, and collaborating with a wide array of system partners as we try to find unique and out of the box messaging, solutions, and treatments to help save lives. As we continue to navigate through this complex landscape, let’s remember the importance of staying informed, looking out for one another, and advocating for comprehensive solutions. Together, we can create a safer and more supportive environment for everyone.

Stay informed, stay connected, and take care of yourself,

Sarah Spier

References:

https://www.whitehouse.gov/ondcp/briefing-room/2023/07/12/dr-rahul-gupta-releases-statement-on-cdcs-new-overdose-death-data-showing-a-full-year-of-flattening-overdose-deaths/#:~:text=This%20latest%20CDC%20report%20shows,drugs%2C%20including%20cocaine%20and%20heroin.

https://www.justice.gov/usao/page/file/1083791/download

https://nida.nih.gov/publications/drugfacts/fentanyl#:~:text=Opioids%20are%20a%20class%20of,semi%2Dsynthetic%20or%20synthetic).

https://www.justice.gov/opa/pr/justice-department-announces-charges-against-china-based-chemical-manufacturing-companies